N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide
H-89 dihydrochloride
CAS: 127243-85-0
Molecular Formula: C20H20BrN3O2S
N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide - Names and Identifiers
N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide - Physico-chemical Properties
| Molecular Formula | C20H20BrN3O2S |
| Molar Mass | 446.36 |
| Density | 1.436 |
| Melting Point | 195-200°C |
| Boling Point | 639.7±65.0 °C(Predicted) |
| Flash Point | 361.8°C |
| Solubility | H2O: ≥10mg/mL |
| Vapor Presure | 1.95E-18mmHg at 25°C |
| Appearance | White-like powder |
| Color | off-white |
| pKa | 10.43±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| MDL | MFCD00214120 |
| Physical and Chemical Properties | Solubility: H2O: ≥ 10 mg/mL storage condition: 2-8 ℃ WGK Germany:3 |
| In vitro study | H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca 2+ uptake by the SR and affectes the Ca 32 -sensitivity of the contractile apparatus in rat skinned fibres. |
| In vivo study | H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold. |
N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29350090 |
N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide - Reference Information
| biological activity | H-89 is an effective and selective cAMP-dependent protein kinase A inhibitor with an IC50 value of 48 nM, and its inhibitory effect on PKG,PKC,Casein Kinase and other kinases is very weak. |
| target | IC50: 48 nM (protein kinase A) |
Last Update：2024-04-09 20:52:54
![N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide](http://res.chembk.com/assets/str/2d/1/12/127243-85-0.png)
Supplier List
Spot supply
Product Name: H-89 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: H-89 Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: H-89 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: H-89 Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: H-89 Visit Supplier Webpage Request for quotation
CAS: 127243-85-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 127243-85-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: H-89 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: H-89 Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: H-89 dihydrochloride Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: H-89 Visit Supplier Webpage Request for quotationCAS: 127243-85-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: H-89 Visit Supplier Webpage Request for quotation
CAS: 127243-85-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 127243-85-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History